Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study

BACKGROUND The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is that increasing childhood obesity rates may explain part of this increase, but, as T1D is rare, intervention studies are challenging to perform. The aim of this study was to assess this hypothesis with a Mendelian randomization approach that uses genetic variants as instrumental variables to test for cau...

Bilirubin as a potential causal factor in type 2 diabetes risk : a 1 Mendelian randomization study

Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study.

Circulating bilirubin, a natural antioxidant, is associated with decreased risk of type 2 diabetes (T2D), but the nature of the relationship remains unknown. We performed Mendelian randomization in a prospective cohort of 3,381 participants free of diabetes at baseline (age 28-75 years; women 52.6%). We used rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an instru...

Mendelian randomization studies of biomarkers and type 2 diabetes.

Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomization studies that examined potential causal effects of biomarkers on T2D. To rep...

Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.

BACKGROUND Coffee is one of the most widely consumed beverages. We tested the hypothesis that genetically high coffee intake is associated with low risk of obesity, metabolic syndrome and type 2 diabetes, and with related components thereof. METHODS We included 93,179 individuals from two large general population cohorts in a Mendelian randomization study. We tested first whether high coffee ...